Human Fibroblast-Like Synoviocytes: Rheumatoid Arthritis: HFLS-RA 人纖維母細胞樣滑膜細胞：類風濕性關節炎：HFLS-RA
產品型號： 408RAK-05a
Human Fibroblast-Like Synoviocytes: Rheumatoid Arthritis (HFLS-RA) provide an excellent cellular model for studying synoviocyte physiology in relation to development and treatment of rheumatoid arthritis.
HFLS-RA from Cell Applications, Inc. have been used in research to evaluate:
- Signaling pathways implicated in the development of joint inflammation and rheumatoid arthritis
- Contribution of EBV to nonresolving rheumatoid arthritis inflammation through inducing IL-6 production by synoviocytes
- Anti-inflammatory and antirheumatic activity of various compounds, such as celastrol, triptolide, arsenic trioxide, bucillamine, therapeutic lyposomes, anti-IL-6R and anti-CD319 antibodies, inhibitors of NF-κB, methionine aminopeptidase-2, Tpl2, aryl hydrocarbon receptor, p38 MAP kinase
- Beneficial anti-inflammatory effects of low level light therapy
- Causes of metalloproteinase induction in patients with Lyme disease-associated arthritis
- Adenovirus-based siRNA delivery systems
- Causative agents, immunopathological mechanisms and signal transduction pathways leading to joint inflammation in rheumatoid arthritis
- The role of estrogen signaling in increasing inflammation
- Anti-inflammatory properties of herbal compound Sinomenine suggested for rheumatoid arthritis treatment
- Effects of extracellular matrix composition on cell attachment and migration relevant to T-cell function in inflamed tissues
- Involvement of capsid proteins of parvorvirus B19 in activating synoviocyte migration and induction of the inflammatory response leading to acute symmetrical polyarthropathy
- The role of human endogenous retroviruses (HERVs) in development of rheumatoid arthritis, and suggest that activated expression of different forms of HERV contribute to development of rheumatoid arthritis symptoms by different mechanisms
DETAILS
| Tissue | Human synovial tissue from donor w/ rheumatoid arthritis |
| QC | No bacteria, yeast, fungi, mycoplasma, virus |
| Cryovial | 500,000 HFLS-RA frozen in Basal Medium w/ 10% FBS, 10% DMSO |
| Kit | Cryovial frozen HFLS-RA (408RA-05a), Gr Med (415-500), Subcltr Rgnt Kit (090K) |
| Proliferating | Shipped in Gr Med, 3rd psg (flasks or plates) |
| Doublings | At least 5 |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
PRODUCTS
| PRODUCT | SIZE | CAT.# |
| Cryopreserved HFLS-RA, Adult: 5x10^5 Cells (from donor with Rheumotoid Arthritis, Adult), Medium & Subculture Reagents (See Details tab for specifics) | 1 Kit | 408RAK-05a |
| Cryopreserved HFLS-RA, Adult: Frozen HFLS from donor with Rheumotoid Arthritis (5x10^5) | 1 Cryovial | 408RA-05a |
| Proliferating HFLS-RA, Adult: Actively growing, dividing cells in medium, from donor with Rheumotoid Arthritis | T-25 Flask | 409RA-25a |
| Proliferating HFLS-RA, Adult: Actively growing, dividing cells in medium, from donor with Rheumotoid Arthritis | T-75 Flask | 409RA-75a |
RELATED PRODUCTS
| PRODUCT | SIZE | CAT.# |
| HFLS Growth Medium: All-in-one ready-to-use | 500 ml | 415-500 |
| HFLS Growth Medium Kit: Basal medium & growth supplement sold together packaged separately | Yields 500 ml | 415K-500 |
| HFLS Basal Medium: Basal medium (contains no growth supplement). Add GS before use. | 500 ml | 414-500 |
| HFLS Growth Supplement: Added to Basal Medium to create Growth Medium | 50 ml | 415-GS |
| Subculture Reagent Kit: 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution | 1 Kit | 090K |
EXTENDED FAMILY PRODUCTS
| PRODUCT | SIZE | CAT.# |
| HFLS-RA RNA, Adult: Total RNA prepared from Human Fibroblast-Like Synoviocytes-Rheumatoid Arthritis, adult | 10 ug | 408RA-R10a |
| HFLS-RA RNA, Adult: Total RNA prepared from Human Fibroblast-Like Synoviocytes-Rheumatoid Arthritis, adult | 25 ug | 408RA-R25a |
| HFLS Growth Medium wo Antibiotics: Growth medium without antibiotics | 500 ml | 415A-500 |
| HFLS Growth Medium wo FBS: Growth medium without FBS | 500 ml | 415F-500 |
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